Cel Signal exchange mediates specificity in legume-Rhizobium associations. Plant roots excrete many compounds, amongst which are flavonoids that activate nodulation genes within the bacteria. In turn, these nodulation proteins direct the synthesis of lipo-oligosaccharides (Nod-factors) which induce root-hair curling and nodulation on the legume. Therefore, several lipo-oligosaccharides will be synthesized in the framework of this project and screened for their biological activity. Rhizobia that are capable of nodulating many legumes secrete various highly modified Nod-factors. For example, Rhizobium sp. NGR234, which nodulates more than 100 legume genera, produces at least 36 different Nod-factors. Amongst them are molecules in which the terminal non-reducing glucosamine is N-acylated with vaccenic or palmitic acids, is N-methylated, and carries one or two carbamoyl groups. The reducing N-acetyl-glucosamine residue is substituted on position 6 with 2-O-methyl-L-fucose which may be acetylated, or sulphated, or non-substituted. All three internal residues are N-acetylated. At pico- to nano-molar concentrations, these signal molecules exhibit symbiotic activity. Some of these NodNGR factors are necessary for the nodulation of a particular plant, others for different legumes. To confirm the structures, and to isolate legume proteins involved in reception/binding, the Nod-factors of Rhizobium sp. NGR234 will be completely synthesised. Program(-y) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Temat(-y) 33 - Organic Chemistry and Polymers Zaproszenie do składania wniosków Data not available System finansowania Data not available Koordynator Université de Genève Wkład UE Brak danych Adres Chemin de l'Impératrice 1 1292 Chambésy - Genève Szwajcaria Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Russian Academy of Sciences Rosja Wkład UE Brak danych Adres 117334 Moscow Zobacz na mapie Koszt całkowity Brak danych Universität Konstanz Niemcy Wkład UE Brak danych Adres 78434 Konstanz Zobacz na mapie Koszt całkowity Brak danych Université de Genève Szwajcaria Wkład UE Brak danych Adres 1211 Genève 4 Zobacz na mapie Koszt całkowity Brak danych
