Objective The physical state of protein molecules known as the molten globule state has been discovered and extensively characterised at the Institute of Protein Research, Pushchino, Russia. It has been proposed, or proved on an experimental basis, that this state plays a physiological role in several processes. This collaborative project will consist in the study of: the influence of conditions that mimic the environment near membranes on the physical state of retinol-binding proteins; the role of structural transitions in the process of targeted delivery of vitamin A derivatives to physiological acceptors; and the structural features of the molten globule state of all proteins of distinct topologies, ranging from all helical to all sheet proteins, including retinol-binding protein, cellular retinol-binding protein, lysozyme, a-lactamase, as well as recombinant chimeric proteins. The methodologies that will be used include high resolution NMR, UV circular dichroism, fluorescence, IR spectroscopy, microcalorimetry, hydrodynamic techniques and X-ray crystallography. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Topic(s) 42 - Physical Chemical Biology Call for proposal Data not available Funding Scheme Data not available Coordinator Università degli Studi di Parma EU contribution No data Address Viale delle Scienze 78 43100 Parma Italy See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all Interdisciplinair Research Centrum Belgium EU contribution No data Address 8500 Kortrijk See on map Total cost No data Russian Academy of Sciences Russia EU contribution No data Address 142292 Pushchino, Moscow Region See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address South Parks Road OX1 3QT OXFORD See on map Total cost No data
