Objectif The physical state of protein molecules known as the molten globule state has been discovered and extensively characterised at the Institute of Protein Research, Pushchino, Russia. It has been proposed, or proved on an experimental basis, that this state plays a physiological role in several processes. This collaborative project will consist in the study of: the influence of conditions that mimic the environment near membranes on the physical state of retinol-binding proteins; the role of structural transitions in the process of targeted delivery of vitamin A derivatives to physiological acceptors; and the structural features of the molten globule state of all proteins of distinct topologies, ranging from all helical to all sheet proteins, including retinol-binding protein, cellular retinol-binding protein, lysozyme, a-lactamase, as well as recombinant chimeric proteins. The methodologies that will be used include high resolution NMR, UV circular dichroism, fluorescence, IR spectroscopy, microcalorimetry, hydrodynamic techniques and X-ray crystallography. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 42 - Physical Chemical Biology Appel à propositions Data not available Régime de financement Data not available Coordinateur Università degli Studi di Parma Contribution de l’UE Aucune donnée Adresse Viale delle Scienze 78 43100 Parma Italie Voir sur la carte Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Interdisciplinair Research Centrum Belgique Contribution de l’UE Aucune donnée Adresse 8500 Kortrijk Voir sur la carte Coût total Aucune donnée Russian Academy of Sciences Russie Contribution de l’UE Aucune donnée Adresse 142292 Pushchino, Moscow Region Voir sur la carte Coût total Aucune donnée THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Royaume-Uni Contribution de l’UE Aucune donnée Adresse South Parks Road OX1 3QT OXFORD Voir sur la carte Coût total Aucune donnée
