Objective It is now firmly established that antibodies can act as efficient catalysts. These catalytic antibodies (abzymes) are classically elicited by using transition state analogues as antigens. The Russian group participating in this project has pioneered an alternative idea, i.e. possible catalytic activity of anti-idiotypic antibodies, and has demonstrated the presence of natural catalytic autoantibodies in sera of patients with autoimmune diseases. On the other hand, the French group, also participating in this project, has demonstrated the possibility of eliciting catalytic anti-idiotypic antibodies as internal images of enzyme active sites used as antigens. This project, a joint investigation, is devoted to the search for new variants of natural catalytic antibodies and their comparison with corresponding analogues elicited by the anti-idiotypic approach. The project includes the study of general principles of antibody mediated catalysis and cloning of selected antibody genes in order to model and analyse the three-dimensional structures of their variable domains. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Topic(s) 44 - Biotechnology Call for proposal Data not available Funding Scheme Data not available Coordinator Le Biopole Végétal EU contribution No data Address 60206 Compiègne France See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA Italy EU contribution No data Address Via Pontina Km 30.6 00040 Pomezia Roma See on map Total cost No data National Academy of Sciences of Ukraine Ukraine EU contribution No data Address 252022 Kiev See on map Total cost No data Russian Academy of Medical Sciences Russia EU contribution No data Address 115522 Moscow See on map Total cost No data Russian Academy of Sciences Russia EU contribution No data Address 117984 Moscow See on map Total cost No data
