Natural history of hepatitis C virus: heterogeneity of strains circulating in Russia, Belarus, and Moldova

Informations projet

N° de convention de subvention: INTAS-94-3255

Date de début 1 Mars 1995

Date de fin 28 Février 1997

Financé au titre de

• International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Coût total € 0,00

Contribution de l’UE € 20 000,00

Coordonné par

Universitätsklinikum Essen
Germany

Objectif

At least six types (genotypes) of the hepatitis C virus (HCV) exist and circulate in different parts of the world. Different genotypes of HCV appear to possess different pathogenic properties and different sensitivity to interferon treatment. Nothing is known about genotypes of HCV circulating in Russia, Belarus, and Moldova, countries highly endemic for HCV infection.

The objectives of this project are: identification of HCV strains circulating in blood donors and patients with different forms of hepatitis C; HCV genotyping, cloning and partial sequencing of representatives of all identified types and subtypes; search for recombinant viruses and new genotypes; analysis of HCV genome heterogeneity and the peculiarities of its evolution; search for a possible correlation or association between HCV genotypes and their biological properties, including replication in tissue culture.

The results of these studies will improve the understanding of the natural history of HCV and the possible impact of the evolution of the virus on the epidemiology and clinical characteristics of HCV infection in general, and in three NIS countries in particular.

Programme(s)

• IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993-

Thème(s)

• 44 - Biotechnology

Appel à propositions

Data not available

Régime de financement

Data not available

Coordinateur

Universitätsklinikum Essen

• Contribution de l’UE: Aucune donnée
• Adresse: Hufelandstraße 55 ; 45122 Essen ; Allemagne
• Coût total: Aucune donnée

Participants (4)

Centre for Hygiene and Epidemiology

Biélorussie

• Contribution de l’UE: Aucune donnée
• Adresse: 220099 Minsk
• Coût total: Aucune donnée

Hospital for Infectious Diseases

Moldavie

• Contribution de l’UE: Aucune donnée
• Adresse: 277004 Kishinau
• Coût total: Aucune donnée

Lund University

Suède

• Contribution de l’UE: Aucune donnée
• Adresse: 20502 Malmö
• Coût total: Aucune donnée

Russian Academy of Medical Sciences

Russie

• Contribution de l’UE: Aucune donnée
• Adresse: 123098 Moscow
• Coût total: Aucune donnée