Cel Participation of adenosine in the modulation of excitatory synaptic transmission and Ca-dependent release of adenine dinucleotides in the mammalian brain are among numerous recent indications that the functional roles of adenosine and related substances are much more diversiform than previously expected. Different methods will be combined: to provide pharmacological characteristics of the binding sites for naturally occurring adenine nucleotides (Ulm); to compare these data with the pharmacology of excitatory synaptic transmission in hippocampus (Kiev and Ulm); to study the action of adenine nucleotides on Ca channels in hippocampal pyramidal neurones and on purinoreceptors in sensory neurones (Madrid and Kiev); to synthesise new adenosine analogues (St.Petersburg). The methods used will include binding and release measurements, electrophysiological experiments and synthesis of new substances. The existing long-term co-operation and complementary tasks of the different groups will guarantee an added scientific value as a result of this transnational collaboration. This neuropharmacological approach fits well into the European Decade of Brain and will also contribute to co-operative economical and technological approaches between NlS and west European countries. In conclusion this project presents considerable perspectives to the understanding of brain function both in health (including learning and memory) and disease (epyleptogenesis, seizures etc.), as well as to drug development. Program(-y) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Temat(-y) 45 - Pharmacology Zaproszenie do składania wniosków Data not available System finansowania Data not available Koordynator Universität Ulm - Klinikum Wkład UE Brak danych Adres Helmholtzstraße 20 89081 Ulm Niemcy Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko National Academy of Sciences of Ukraine Ukraina Wkład UE Brak danych Adres 252601 Kiev Zobacz na mapie Koszt całkowity Brak danych Universidad Complutense de Madrid Hiszpania Wkład UE Brak danych Adres 28040 Madrid Zobacz na mapie Koszt całkowity Brak danych
