Objectif Glutamate is the major excitatory neurotransmitter mediating communication between neurons in the brain. In the cerebellum glutamatergic transmission underlies information processing, contributing to the control of movement of the body, and thereafter changes in the strength of glutamatergic synapses may allow the brain to store patterns of motor activity. Although the basic mode of operation of cerebellar glutamatergic synapses is understood, there are severe defects in our knowledge of: how the strengths of these synapses may be modulated during normal function in pathological conditions like brain anoxia and during development of the nervous system. In order better to understand the topics outlined above, patch-clamp techniques will be used on slices of cerebellum in vitro to study the fundamental properties of cerebellar glutamatergic synapses. In particular, the effects of the modulatory agents adenosine, arachidonic acid, enkephalin and corticotropin releasing factor on the synapses from parallel fibres and climbing fibres to Purkinje cells will be tested, with a view to understanding how the gains of these synapses are adjusted on short and long time scales. These experiments will significantly improve the understanding of information processing in the cerebellum, and may give insight into how it malfunctions in pathological conditions. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 45 - Pharmacology Appel à propositions Data not available Régime de financement Data not available Coordinateur UNIVERSITY COLLEGE LONDON Contribution de l’UE Aucune donnée Adresse Gower Street LONDON Royaume-Uni Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Ecole Normale Supérieure France Contribution de l’UE Aucune donnée Adresse 75230 Paris Voir sur la carte Coût total Aucune donnée National Academy of Sciences of Ukraine Ukraine Contribution de l’UE Aucune donnée Adresse GSP 252601 Kiev Voir sur la carte Coût total Aucune donnée
