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Integration at pilot scale of high cell density bioreactor operation with ultra fast on-line downstream processing

Ziel



This project aims at validating - at pilot scale - a continuous process whereby heterologous glycoproteins secreted from mammalian cells propagated in continuously stirred tank reactor are extensively purified by an uninterrupted downstream processing.

The original aspects of the Demonstration are:
- integration of high cell density cultivation with ultra fast on-line downstream processing - validation of sonoperfusion at 8L- and 20L culture volume scale - validation of the "high cell concentration per unit culture volume" concept - use of state-of-the art support for Expanded Bed specific Adsorption (EBSA) - use of specific solid phase screening methods for the selection of chromatographic ligands.

Wissenschaftliches Gebiet

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Aufforderung zur Vorschlagseinreichung

Data not available

Finanzierungsplan

CSC - Cost-sharing contracts

Koordinator

Computer Cell Culture Center SA
EU-Beitrag
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Adresse
20,Place du Parc
7000 Mons
Belgien

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Beteiligte (4)

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Letzte Aktualisierung: 7 Dezember 2001

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/BIO4980551/de

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