Cel The consortium has been quite successful in promoting the pathophysiological basis of therapeutic approaches to overcome the acute radiation syndrome in man, using the most advanced technologies available. There is no doubt that the Consortium of Scientists in Rotterdam, Paris, Rome and Ulm has very successfully contributed to the improvement of existing and the development of new approaches to manage accidentally radiation exposed persons.It is the purpose of this proposal to suggest research activities relevant to the improvement of existing and the development of new approaches in the management of accidentally radiation exposed persons. It is a response to the technical contents of the EC nuclear fission safety programme 1991-1993 in which research tasks are described in the field of radiation syndromes and their treatment after radiation exposure of large parts of the body. The participating 4 laboratories are prepared to perform research in 5 major areas : 1. Pathophysiology of radiation induced alterations of the immuno-hematopoietic system, alterations of the immuno-hematopoietic system, the respiratory and gastrointestinal systems and the central nervous system including connective tissue and stromal cell changes. 2. Diagnosis of the radiation syndromes by preclinical and clinical approaches. 3. Prevention of the development of severe radiation syndromes. 4. Therapy of the radiation syndromes by the use of hemopoietic growth factors, by the modulation of the immune responses and by new approaches in the use of bone marrow reconstitution by stem cell transfusion. The collaborating laboratories will perform clinical studies in patients subjected to total body irradiation in preparation for stem cell transplantation and experimental research using several in-vivo and in-vitro models as well as biomathematical aproaches. The laboratories are well equipped to perform the necessary research using cell system, and cell biology tools as well as novel methods of molecular biology. Dziedzina nauki natural sciencesphysical sciencesnuclear physicsnuclear fissionmedical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinetransplantation Program(-y) FP3-NFS 1 - Research and education programme (Euratom) in the field of nuclear fission safety, 1990-1994 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator Universität Ulm Wkład UE Brak danych Adres Albert-Einstein-Allee 89081 Ulm Niemcy Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Centre International de Radiopathologie Francja Wkład UE Brak danych Adres 92260 Fontenay-aux-Roses Zobacz na mapie Koszt całkowity Brak danych Ente per le Nuove Tecnologie l'Energia e l'Ambiente (ENEA) Włochy Wkład UE Brak danych Adres Via Anguillarese 301 00060 Santa Maria di Galeria Roma Zobacz na mapie Koszt całkowity Brak danych Erasmus Universiteit Rotterdam Niderlandy Wkład UE Brak danych Adres 3000 DR Rotterdam Zobacz na mapie Koszt całkowity Brak danych
