Objective Susceptibility genes and environmental factors contribute to the rising incidence of melanoma in Europe. Tumor associated antigens on melanomas can be recognized by immune effectors. These antigens are the focus of immunotherapy protocols. Information is lacking, however, concerning expression of tumour associated antigens and the activation status of immune effectors at initial stages of tumour suppressor gene in melanocytes. The concordant expression of a tumour associated antigen will allow monitoring of the activation status of antigen-specific lymphocytes during tumour progression. This information is essential for the design of tumour antigen vaccination and other therapeutic protocols. This project requires a pluridisciplinary effort by groups involved in(i) development of models of oncogenesis by somatic genetics in mice;(ii) identification of melanoma associated antigens in humans and;(iii) monitoring activation or inactivation in vivo and targeting of immune effectors or antigen presenting cells. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicineoncologyskin cancermelanomamedical and health sciencesbasic medicineimmunologyimmunotherapy Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE EU contribution No data Address Parc Scientifique et Technologique de Luminy 13288 MARSEILLE France See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY Belgium EU contribution No data Address Avenue Hippocrate 75, ICP 75.50 BRUXELLES See on map Links Website Opens in new window Total cost No data THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL Netherlands EU contribution No data Address 121,Plesmanlaan 121 1066 CX AMSTERDAM See on map Total cost No data
