Objetivo Susceptibility genes and environmental factors contribute to the rising incidence of melanoma in Europe. Tumor associated antigens on melanomas can be recognized by immune effectors. These antigens are the focus of immunotherapy protocols. Information is lacking, however, concerning expression of tumour associated antigens and the activation status of immune effectors at initial stages of tumour suppressor gene in melanocytes. The concordant expression of a tumour associated antigen will allow monitoring of the activation status of antigen-specific lymphocytes during tumour progression. This information is essential for the design of tumour antigen vaccination and other therapeutic protocols. This project requires a pluridisciplinary effort by groups involved in(i) development of models of oncogenesis by somatic genetics in mice;(ii) identification of melanoma associated antigens in humans and;(iii) monitoring activation or inactivation in vivo and targeting of immune effectors or antigen presenting cells. Ámbito científico natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicineoncologyskin cancermelanomamedical and health sciencesbasic medicineimmunologyimmunotherapy Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Aportación de la UE Sin datos Dirección Parc Scientifique et Technologique de Luminy 13288 MARSEILLE Francia Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY Bélgica Aportación de la UE Sin datos Dirección Avenue Hippocrate 75, ICP 75.50 BRUXELLES Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL Países Bajos Aportación de la UE Sin datos Dirección 121,Plesmanlaan 121 1066 CX AMSTERDAM Ver en el mapa Coste total Sin datos