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Regulation of expresssion and function of hfe, a novel regulatory protein of iron homeostasis : production of new tools to hereditary hemochromatosis and associated chronic diseases.

Ziel

HFE molecules have a pivotal role in controlling iron metabolism, as best exemplified by classical hereditary hemochromatosis, the most common hereditary disorder in European populations. Tools have been and will be developed (i.e. HFE specific monoclonal antibodies, KO and HFE transgenic mice) in the clustered laboratories to define HFE expression and mode of action in normal tissues and malignant cells, in cell activation, in virus-infected cells (specially with chronic viruses such as hepatitis), and in various iron-overload related pathologies. Complementary approaches (characterization of HFE promoter, biochemistry of HFE, iron metabolism exploration, cellular employ) will be combined for a comprehensive resolution of iron metabolism control. A particular effort to dissect the connections that exists between iron metabolism, HFE, and immune system, will be made. Experimental tools and gained knowledge will be utilized to explore human pathological situations associated with iron disorders, their early diagnosis and the development of novel therapeutic modalities.

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CSC - Cost-sharing contracts

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INSTITUT PASTEUR
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Rue du Docteur Roux 25
75724 PARIS
Frankreich

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Letzte Aktualisierung: 12 April 2005

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Permalink: https://cordis.europa.eu/project/id/QLG1-CT-1999-00665/de

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