Objective Type 2 diabetes is a major global health problem, which is undergoing an epidemic development. Effective intervention and treatment require the understanding of the genetic and molecular mechanisms involved. The objectives of this proposal are to identify at least 800 healthy first-degree relatives to Type 2 diabetic subjects. And a similar control group lacking known genetic predisposition. Extensive and novel technology will be used to characterize clinical subphenotypes. Adipose and muscle biopsies will be obtained for analyses of gene expression using the novel cDNA array technology. Differentially expressed cDNAs will be identified and cloned and biological functions of novel proteins identified. Transgenic/knock-out animals will be generated to identify in vivo functions. In parallel, focused research will be performed aimed at identifying candidate genes, including intracellular signalling molecules and nuclear receptor transcription factors. Fields of science natural sciencesbiological sciencescell biologycell signalingnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineendocrinologydiabetes Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator GOETEBORG UNIVERSITY EU contribution No data Address Sahlgrenska University Hospital - Groena Straket, 413 45 GOETEBORG Sweden See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all AUTONOMOUS UNIVERSITY OF BARCELONA Spain EU contribution No data Address Campus Universitari Bellaterra 08193 BELLATERRA See on map Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Laurent Fries 1 67404 ILLKIRCH GRAFFENSTADEN See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue de Tolbiac, 101 75654 PARIS See on map Total cost No data THE UNIVERSITY OF TUEBINGEN Germany EU contribution No data Address Wilhelmstrasse 5 72074 TUEBINGEN See on map Total cost No data UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy EU contribution No data Address VIA ORAZIO RAIMONDO 18 ROMA See on map Links Website Opens in new window Total cost No data UNIVERSITY OF KUOPIO Finland EU contribution No data Address Savilahdentie 9 1627 KUOPIO See on map Total cost No data Università degli Studi di Napoli 'Federico II' Italy EU contribution No data Address Corso Umberto I 34 80138 Napoli See on map Links Website Opens in new window Total cost No data
