Objective The general objective of this program is to understand the principal mechanisms governing apoptosis or programmed cell depth, both in normal cells and in cancer cells, to unravel differences in physiology and pathology of cell death regulation, and to design novel strategies for the correction of disease-associated imbalances in cell death regulation. In particular, we are interested in understanding how cancer cells become apoptosis resistant and how this resistance can be overcome. A consortium of 11 leading research teams from 7 different countries will identify and characterize novel cell death inducing or cell death inhibitory pathways via a multidisciplinary approach integrating advanced technologies of Molecular and Cellular Biology. In addition, the group will monitor cancer cells for alterations in such cell death modulator pathways, and manipulate them to kill chemotherapy-resistant tumour cells. Fields of science medical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicinephysiology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE EU contribution No data Address Rue Guy Môquet 19 94801 Villejuif France See on map Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Parc Scientifique et Technologique de Luminy 13288 MARSEILLE See on map Total cost No data FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Belgium EU contribution No data Address Rijvisschestraat 120 9052 ZWIJNAARDE See on map Total cost No data GERMAN CANCER RESEARCH CENTER Germany EU contribution No data Address Im Neuenheimer Feld 280 69120 HEIDELBERG See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Parc Scientifique de Luminy 13288 MARSEILLE See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Lancaster Road University of Leicester Hodgkin Bui LE1 9HN Leicester See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution No data Address Trinity Lane, The Old Schools, CB2 1TN CAMBRIDGE See on map Total cost No data THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Ireland EU contribution No data Address Trinity College 2 DUBLIN See on map Total cost No data UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy EU contribution No data Address VIA ORAZIO RAIMONDO 18 ROMA See on map Links Website Opens in new window Total cost No data University of Ulm Germany EU contribution No data Address Albert-Einstein-Allee 11 89070 Ulm See on map Total cost No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution No data Address Herzel Street 2 P.O.Box 26 REHOVOT See on map Links Website Opens in new window Total cost No data