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Fundamental mechanisms of apoptosis/cell death regulation in normal and cancer cells.

Objective

The general objective of this program is to understand the principal mechanisms governing apoptosis or programmed cell depth, both in normal cells and in cancer cells, to unravel differences in physiology and pathology of cell death regulation, and to design novel strategies for the correction of disease-associated imbalances in cell death regulation. In particular, we are interested in understanding how cancer cells become apoptosis resistant and how this resistance can be overcome. A consortium of 11 leading research teams from 7 different countries will identify and characterize novel cell death inducing or cell death inhibitory pathways via a multidisciplinary approach integrating advanced technologies of Molecular and Cellular Biology. In addition, the group will monitor cancer cells for alterations in such cell death modulator pathways, and manipulate them to kill chemotherapy-resistant tumour cells.

Call for proposal

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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
EU contribution
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Address
Rue Guy Môquet 19
94801 Villejuif
France

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Total cost
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Participants (10)