Objetivo This projects seeks to identify and define the role of genes located within two non- overlapping regions (LOH regions 1 and 2) at chromosome 11q23 that are frequently deleted in various types of human neoplasme.The project proposes to determine the trans- criptional map of these regions by mapping ESTs and sequencing the entire LOH region 2. It also proposes to characterize resident genes for their expression pattern and presence of mutations tumours samples. For genes involved in tumorigenesis by mutation/expression studies functional studies involving suppression of tumorigenicity assays, animal models and identification of interacting proteins will be conducted. An internal service, we will develop a tumour databank that should serve the scientific needs of the consortium. We expect to open the way to the development of new molecular diagnostics and to the identification of new biological targets for therapeutic intervention. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncologynatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysisnatural sciencesbiological sciencesgeneticschromosomes Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-8. - Research into genomes and diseases of genetic origin Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador UNIVERSITÀ DEGLI STUDI DI FERRARA Aportación de la UE Sin datos Dirección Via Luigi Borsari, 46 44100 FERRARA Italia Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY OF SOUTHAMPTON Reino Unido Aportación de la UE Sin datos Dirección c/o Duthie Building, Southampton General Hospital SO16 6YD SOUTHAMPTON Ver en el mapa Coste total Sin datos University of Ulm Alemania Aportación de la UE Sin datos Dirección Albert-Einstein-Allee 11 89070 Ulm Ver en el mapa Coste total Sin datos
