Objetivo The Pharmacological and biophysical properties of members of the KCNQ family of voltage-dependent potassium channels are similar to those of the M-current. Mutations on any of the know four members underlie hereditary disorders, such as epilepsy, cardiac arrhythmia or deafness. Furthermore, several pharmacological studies suggest an important role of this current in cognition processes. Thus, the M-current is a prime target for development of new drugs with potential therapeutically value. This proposal focuses in the physiological role, pharmacological and molecular properties and neuronal distribution of the KCNQ (M) - channel. It aims towards the development of new tools for the study of this channels, to the discovery of new drugs that, by affecting the KCNQ/M M-channels, may be useful in the treatment of some neurological disorders, such as epilepsy and Alzheimer's disease, and to the establishment of a mouse model of deafness. Ámbito científico medical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmiamedical and health sciencesbasic medicineneurologydementiaalzheimernatural scienceschemical sciencesinorganic chemistryalkali metalsnatural sciencesbiological sciencesgeneticsmutation Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-9. - Neurosciences Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Aportación de la UE Sin datos Dirección Calle Serrano 117 MADRID España Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo DIVERDRUGS S.L. España Aportación de la UE Sin datos Dirección Santa Eulalia 240 08902 HOSPITALET DEL LLOBREGAT Ver en el mapa Coste total Sin datos NEUROSEARCH A/S Dinamarca Aportación de la UE Sin datos Dirección Pederstrupvej 93 2750 BALLERUP Ver en el mapa Coste total Sin datos UNIVERSITY OF OSLO Noruega Aportación de la UE Sin datos Dirección Problemveien 1 0316 OSLO Ver en el mapa Coste total Sin datos Birkbeck College, University of London Reino Unido Aportación de la UE Sin datos Dirección Malet Street, Bloomsbury WC1E 7HX London Ver en el mapa Coste total Sin datos
