Cel The Pharmacological and biophysical properties of members of the KCNQ family of voltage-dependent potassium channels are similar to those of the M-current. Mutations on any of the know four members underlie hereditary disorders, such as epilepsy, cardiac arrhythmia or deafness. Furthermore, several pharmacological studies suggest an important role of this current in cognition processes. Thus, the M-current is a prime target for development of new drugs with potential therapeutically value. This proposal focuses in the physiological role, pharmacological and molecular properties and neuronal distribution of the KCNQ (M) - channel. It aims towards the development of new tools for the study of this channels, to the discovery of new drugs that, by affecting the KCNQ/M M-channels, may be useful in the treatment of some neurological disorders, such as epilepsy and Alzheimer's disease, and to the establishment of a mouse model of deafness. Dziedzina nauki medical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmiamedical and health sciencesbasic medicineneurologydementiaalzheimernatural scienceschemical sciencesinorganic chemistryalkali metalsnatural sciencesbiological sciencesgeneticsmutation Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-9. - Neurosciences Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Wkład UE Brak danych Adres Calle Serrano 117 MADRID Hiszpania Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko DIVERDRUGS S.L. Hiszpania Wkład UE Brak danych Adres Santa Eulalia 240 08902 HOSPITALET DEL LLOBREGAT Zobacz na mapie Koszt całkowity Brak danych NEUROSEARCH A/S Dania Wkład UE Brak danych Adres Pederstrupvej 93 2750 BALLERUP Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF OSLO Norwegia Wkład UE Brak danych Adres Problemveien 1 0316 OSLO Zobacz na mapie Koszt całkowity Brak danych Birkbeck College, University of London Zjednoczone Królestwo Wkład UE Brak danych Adres Malet Street, Bloomsbury WC1E 7HX London Zobacz na mapie Koszt całkowity Brak danych
