Obiettivo Seven European laboratories have associated to evaluate the potential of defective HSV vectors, including helper-free HSV amplicons, as vaccine for the delivery of foreign antigens. The model antigens will be derived from human viruses of high public health concern, such as HCV, HIV-1 and HPV-16, each causing significant morbidity and mortality and substantial economic burden. No effective vaccines are available to prevent or treat these viral infections. To this end we plan to determine the conditions required to optimise delivery, expression and presentation of foreign antigens, including the in vivo synthesis of empty virus-like HCV and HPV-16 particles. Significant innovations will be the use of a unique in its nature vector (the amplicon), never used before, as vaccine vector and the attempt to manipulate the immune response by attracting monocytes to sites of infection and inducing their differentiation into dendritic cells. Campo scientifico medical and health scienceshealth sciencespublic healthmedical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis Cmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health scienceshealth sciencesinfectious diseasesDNA viruses Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-2. - Key action Control of Infectious Diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITE CLAUDE BERNARD LYON 1 Contributo UE Nessun dato Indirizzo 43,Boulevard du 11 Novembre 1918, 43 69622 VILLEURBANNE Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto GERMAN CANCER RESEARCH CENTER Germania Contributo UE Nessun dato Indirizzo 242,Im Neuenheimer Feld 242 69120 Heidelberg Mostra sulla mappa Costo totale Nessun dato HELLENIC PASTEUR INSTITUTE Grecia Contributo UE Nessun dato Indirizzo 127,Vassilissis Sofias Avenue 127 11521 ATHENS Mostra sulla mappa Costo totale Nessun dato LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Germania Contributo UE Nessun dato Indirizzo Geschwister-Scholl-Platz 1 80539 MUENCHEN Mostra sulla mappa Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Regno Unito Contributo UE Nessun dato Indirizzo John Radcliffe Hospital OX3 9DU OXFORD Mostra sulla mappa Costo totale Nessun dato UNIVERSITÀ DEGLI STUDI DI FERRARA Italia Contributo UE Nessun dato Indirizzo Via Luigi Borsari 46 44100 Ferrara Mostra sulla mappa Costo totale Nessun dato
