Objectif Development of a safe and effective vaccine against human respiratory syncytial virus, and its close bovine relative, remains a high priority. These viruses are the most important cause of severe respiratory infections in very young children and calves. We intend to use recently developed techniques for rescuing negative- stranded RNA viruses from cDNA copies of the entire genome. This approach offers the possibility of using highly developed genetic engineering techniques for introducing desired mutations in the viral genome. Minigenome amplication and alternative assays will be used for rapid screening of promising mutations that may be then transferred to full-length cDNA clones for virus rescue. Mutant viruses will be tested in cell and organ cultures for growth and induction of key regulatory molecules. Viruses with interesting phenotypes will be tested in animal models, including calves as a natural host of bovine respiratory syncytial virus. Champ scientifique medical and health scienceshealth sciencesinfectious diseasesRNA virusesnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesgeneticsmutation Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-2. - Key action Control of Infectious Diseases Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur INSTITUTE OF HEALTH CARLOS III Contribution de l’UE Aucune donnée Adresse Carretera de Majadahonda a Pozuelo 28220 MAJADAHONDA Espagne Voir sur la carte Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUTE FOR ANIMAL HEALTH Royaume-Uni Contribution de l’UE Aucune donnée Adresse Compton Laboratory RG20 7NN NEWBURY Voir sur la carte Coût total Aucune donnée LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Allemagne Contribution de l’UE Aucune donnée Adresse Geschwister-Scholl-Platz 1 80539 MUENCHEN Voir sur la carte Coût total Aucune donnée SCHOOL OF VETERINARY MEDICINE, HANNOVER Allemagne Contribution de l’UE Aucune donnée Adresse Buenteweg 17 30559 HANNOVER Voir sur la carte Coût total Aucune donnée UNIVERSITY OF WARWICK Royaume-Uni Contribution de l’UE Aucune donnée Adresse GIBBET HILL ROAD COVENTRY Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
