Cel Development of a safe and effective vaccine against human respiratory syncytial virus, and its close bovine relative, remains a high priority. These viruses are the most important cause of severe respiratory infections in very young children and calves. We intend to use recently developed techniques for rescuing negative- stranded RNA viruses from cDNA copies of the entire genome. This approach offers the possibility of using highly developed genetic engineering techniques for introducing desired mutations in the viral genome. Minigenome amplication and alternative assays will be used for rapid screening of promising mutations that may be then transferred to full-length cDNA clones for virus rescue. Mutant viruses will be tested in cell and organ cultures for growth and induction of key regulatory molecules. Viruses with interesting phenotypes will be tested in animal models, including calves as a natural host of bovine respiratory syncytial virus. Dziedzina nauki medical and health scienceshealth sciencesinfectious diseasesRNA virusesnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesgeneticsmutation Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-2. - Key action Control of Infectious Diseases Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator INSTITUTE OF HEALTH CARLOS III Wkład UE Brak danych Adres Carretera de Majadahonda a Pozuelo 28220 MAJADAHONDA Hiszpania Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUTE FOR ANIMAL HEALTH Zjednoczone Królestwo Wkład UE Brak danych Adres Compton Laboratory RG20 7NN NEWBURY Zobacz na mapie Koszt całkowity Brak danych LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Niemcy Wkład UE Brak danych Adres Geschwister-Scholl-Platz 1 80539 MUENCHEN Zobacz na mapie Koszt całkowity Brak danych SCHOOL OF VETERINARY MEDICINE, HANNOVER Niemcy Wkład UE Brak danych Adres Buenteweg 17 30559 HANNOVER Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF WARWICK Zjednoczone Królestwo Wkład UE Brak danych Adres GIBBET HILL ROAD COVENTRY Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
