Cel Vaccine design has mainly been based on a trial and error method without specific knowledge of requirements in terms of antigen composition and presentation, and the quality of immune response needed. In this project, we will use a methodological approach for designing efficacious and safe marker vaccines based on the identification of immuno-protective antigens, we will use efficient and biologically safe delivery systems and establish the quality of immunity required for prevention of disease and virus transmission. Using nucleic acid vaccine technology, parts of viral genome will be screened for novel immuno-protective antigens by expression library immunisation (ELI). Enhancement of the efficacy and bio safety of nucleic acid vaccines will be sought through1) adjuration CpG motifs,2) favouring T cell immunity through antigen - ubiquitin fusion,3) using auto-replicative Sindbis vectors and respectively4) species restricted promoters. Moreover, we will compare the efficacy of nucleic acid delivery with a potentially effective and safe antigen delivery system based on attenuated Orf virus recombinant vectors. Throughout the project, the type of immune responses will be analysed in relation to the quality if immunity that prevents disease and virus transmission, thereby defining correlates of vaccine induced immune protection. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsmedical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-2. - Key action Control of Infectious Diseases Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS Wkład UE Brak danych Adres BP 53 22440 PLOUFRAGAN Francja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CIDC-LELYSTAD, CENTRAAL INSTITUUT DIERZIEKTE CONTROLE LELYSTAD Niderlandy Wkład UE Brak danych Adres Houtribweg 39 8221 RA LELYSTAD Zobacz na mapie Koszt całkowity Brak danych FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH Niemcy Wkład UE Brak danych Adres Paul Ehrlichstr. 28 72076 TUEBINGEN Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF GDANSK Polska Wkład UE Brak danych Adres 24,Kladki 24 80 822 GDANSK Zobacz na mapie Koszt całkowity Brak danych
