Objectif Gastrointestinal nematodes are a considerable parasitic burden to the livestock industry in the EU. The associated nematodoses are currently controlled by the strategic use of anthelmintic drugs, but this has become unsustainable due to the emergence of anthelmintic resistance and increasing concerns about drug residues entering the food chain and the environment. Novel control strategies are urgently required and vaccination is now a feasible alternative. The proposed collaborative grouping has identified a number of helminth proteases which have potential as vaccine antigens. The aim of the proposed research is, initially, to assess the utility of selected native secreted and somatic proteases to protect against infection with homologous and heterologous nematode species. Subsequently, cDNAs encoding protective proteases will be isolated and expressed in recombinant form for evaluation of their vaccine utility. This work will be underpinned by a definition of the protective properties of the respective antigens and the host's immune response to vaccination. The ultimate aim is the development of monovalent/multivalent nematode vaccines. Champ scientifique medical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-2. - Key action Control of Infectious Diseases Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur MOREDUN RESEARCH INSTITUTE Contribution de l’UE Aucune donnée Adresse Bush Loan Pentlands Science Park EH26 0PZ PENICUIK Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire GENT UNIVERSITY Belgique Contribution de l’UE Aucune donnée Adresse Sint Pietersnieuwstraat 25 9000 GENT Voir sur la carte Coût total Aucune donnée WISE & MUNRO LEARNING RESEARCH Pays-Bas Contribution de l’UE Aucune donnée Adresse 8,Azaleastraat 85 2565 CD DEN HAAG Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
