Objective This project will study basic inmunopathological mechanisms, including cellular and cytokine profiles, related to intraperitoneal immune granulomas seen in vaccinated farmed fish Atlantic salmon, rainbow trout and sea bass following the use of oil-adjuvant vaccines containing Aromas salmonicida, Vibrato angular or Pasteur Ella viscid. Emphasis on the contribution of eosinophilic granular cells/mast cells and of pro-inflammatory mediators and cytokines to granule formation. Techniques ranging from histocytoschemistry to gene expressions studies and ex vivo tissue explants will be used. Results contributing to the development of safer vaccine formulations for fish are expected.The project has shed light on the underlying mechanisms of granuloma formation in vaccinated farmed fish and it has been documented that the characteristics of the vaccine formulation, e.g. extracellular products, antigen content and stability has a bearing on the extent of injection site reactions. It has been shown that different cytokines are produced at the site of injection and that it is also up-regulated in immunocompetent organs like the spleen a few days after vaccination. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator NORWEGIAN SCHOOL OF VETERINARY SCIENCE EU contribution No data Address Ullevaalsveien 72 0033 OSLO Norway See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all ALPHARMA AS Norway EU contribution No data Address Harbitzalleen 3 Skoyen 0212 OSLO See on map Total cost No data ASSOCIACAO DO INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR Portugal EU contribution No data Address Rua de Campo Alegre, 823 4150 PORTO See on map Total cost No data UNIVERSIDAD DE LEON Spain EU contribution No data Address AVENIDA DE LA FACULTAD 25 24071 LEON See on map Total cost No data University of Aberdeen United Kingdom EU contribution No data Address 2 Tillydrone Avenue AB9 2TN Aberdeen See on map Total cost No data
