Obiettivo The objective is to set a scientifically defendable limit of safe exposure to dioxins, as to developmental effects and cancer. The exceptionally wide inter- and intraspecies differences in sensitivity to dioxins will be scrutinised to diminish this major uncertainty factor in risk assessment. To achieve this general objective, a number of specific objectives are set:1. To study the molecular mechanisms of dioxin toxicity in a multidisciplinary manner, utilising the mutated receptor causing a remarkable resistance towards dioxin toxicity2. To resolve in population studies the sensitivity of human being to developmental effects (tooth defect and cleft palate) cancer, and compare these outcomes to results in experimental animals.3. To perform an up-to-date dioxin risk assessment.Scientific approachThe work can be divided to five major parts, all of which contain input by several partners. 1. Mechanistic studies aimed at increasing understanding on the mechanism of toxic actions of dioxins. This is necessary, because there are several serious gaps in the information, and a science-based risk assessment is not possible without understanding the basics. This part utilises mutated dioxin receptor genes which the partners have demonstrated in experimental animals, and by means of molecular biology techniques attempt, to pinpoint the critical steps in toxic mechanisms.2. Human levels in population are established by measuring dioxin-like compounds in fat (breast milk, surgical samples, placentas).3. The sensitivity of human beings to the developmental effects (especially tooth defects in children) is scrutinised in population studies, and compared with the sensitivity of normal and mutated animals to find out the capability of data to predict human effects.4. The risk of cancer is studied in human populations by correlating the cancer risk with dioxin concentrations in the body. Especially important is soft tissue sarcoma which is thought to be associated with dioxin exposure.5. A comprehensive risk assessment exercise is performed on the basis of the whole data set obtained from the proposed studies directed at critical data gaps, and also fully utilising previous information. In an attempt to help decision makers, this continues with a policy-driven risk analysis exercise to illuminate all factors needed in the decision-making process. Campo scientifico medical and health sciencesclinical medicineobstetricsmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesmolecular biology Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-4. - Key action Environment and Health Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore NATIONAL PUBLIC HEALTH INSTITUTE Contributo UE Nessun dato Indirizzo Mannerheimintie 166 HELSINKI Finlandia Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto AZIENDA OSPEDALIERA "OSPEDALE CIVILE DI VIMERCATE" Italia Contributo UE Nessun dato Indirizzo Via Benefattori Ospedale 2 20033 DESIO Mostra sulla mappa Costo totale Nessun dato INSTITUTE OF BIOTECHNOLOGY Lituania Contributo UE Nessun dato Indirizzo 8,Graiciuno Street 8 2600 VILNIUS Mostra sulla mappa Costo totale Nessun dato KAROLINSKA INSTITUTE Svezia Contributo UE Nessun dato Indirizzo Solnavagen 1 171 77 STOCKHOLM Mostra sulla mappa Costo totale Nessun dato LINKOEPING UNIVERSITY Svezia Contributo UE Nessun dato Indirizzo Hus Origo Campus Valla 581 83 LINKOEPING Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF HELSINKI Finlandia Contributo UE Nessun dato Indirizzo Yliopistonkatu 4 00014 HELSINKI Mostra sulla mappa Costo totale Nessun dato
