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Mechanisms of toxicity of asbestos substitute mineral fibres: new approaches to hazard and risk assessment.

Objetivo

This project aims to support the hazard and risk assessment of asbestos substitute fibres. The potential for induction of inflammatory changes, oxidative stress, immunotoxicity and genotoxicity will be eximined for three substitute fibres (glass fibres, rock wool, wollastonite) and compared to that of amosite asbestos. Novel cell culture or whole animal systems will be employed to obtained information on the molecular mechanisms and the dose-response relationships governing the induction of the above toxic effects for use in human population studies. These biomarkers of exposure and early effects for use in human population studies. These biomarkers will be applied, together with already existing biomarkers, in biomonitoring studies of cohorts of fibre workers.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

NATIONAL HELLENIC RESEARCH FOUNDATION
Aportación de la UE
Sin datos
Dirección
Vassileos Constantinou Avenue 48
ATHENS
Grecia

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Enlaces
Coste total
Sin datos

Participantes (6)