Objective Foreseen ResultsThe applied scientific goal of the proposed research is to help in identifying on a cost-benefit basis the most accurate and practical methods to assess hazardous occupational exposures.The present proposal is aimed to evaluate the genetics effects of acrylonitrile in two occupational exposed populations from two plants (one in Portugal and one in Czech Republic). It involves 6 laboratories, 3 from EU-member states (Portugal, Belgium and United Kingdom) and 3 from Central Europe countries (Czech Republic, Slovakia and Hungary). Besides aiming the contribute to a better understanding of the hazardous exposure of man to acrylonitrile, it aims to help validating and optimizing the use of a combination of methods applied to human populations exposed to genotoxic compounds. Three main compartments related to the dose or effects of the hazardous compounds will be evaluated using various assessment methods :Internal dose : mutagenicity in urine, indicators of oxidation stress, induction of cytochrome P450;Biological effective dose : haemoglobin adduct, DNA excision products;Early biological effects : chromosomal aberrations, sister chromatid exchanges, micronuclei and DNA damage (Comet assay). Fields of science natural sciencesbiological sciencesgeneticsDNAnatural scienceschemical scienceselectrochemistryelectrolysisnatural sciencesphysical sciencesastronomyplanetary sciencescometssocial sciencespolitical sciencesgovernment systems Programme(s) FP4-INCO - Specific research, technological development and demonstration programme in the field of cooperation with third countries and international organizations, 1994-1998 Topic(s) 01020301 - Research into occupational medicine Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSIDADE NOVA DE LISBOA EU contribution No data Address 93,Rua da Junqueira 93 1349-008 LISBOA Portugal See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all 'Bela Johan' National Institute of Hygiene Hungary EU contribution No data Address 2-6,Gyali ut 1097 Budapest See on map Total cost No data INSTITUTE OF EXPERIMENTAL MEDICINE - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Czechia EU contribution No data Address Videnska 1083 142 20 PRAHA 4 See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Lancaster Road University of Leicester Hodgkin Bui LE1 9HN Leicester See on map Total cost No data Prague Institute of Advanced Studies Czechia EU contribution No data Address 366,U Michelského Lesa 366 140 00 Praha 4 See on map Total cost No data UNIVERSITY P.J. SAFARIK Slovakia EU contribution No data Address 1,Tr.Snp 1 040 60 KOSICE See on map Total cost No data Université Catholique de Louvain Belgium EU contribution No data Address 72,Avenue E. Mounier 1200 Bruxelles See on map Total cost No data