Obiettivo The aim of the project is to develop a subunit vaccine and novel life-cycle stage specific diagnostics for T. annulated. Protective immunity involves effectors directed at 3 life-cycle stages (sporozoite, merozoite & schizont). Using a novel delivery system six available secreted schizont antigens plus an existing sporozoite & merozoite surface antigen will be tested for protective capacity. Previously noted synergism in protection between the sporozoite & merozoitesurface antigen will be further evaluated. Additional secreted schizont antigens will be isolated. Analysis of the immune response to these antigens will drive the design of further protection trials as will the role of antigenic diversity. Rapid, simple fondant serological diagnostics will be developed & used for epidemiological analysis and to assess the efficacy of novel subunit and existing live vaccines. Campo scientifico medical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF YORK Contributo UE Nessun dato Indirizzo Heslington YORK Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ADNAN MENDERES UNIVERSITY Turchia Contributo UE Nessun dato Indirizzo Isikli AYDIN Mostra sulla mappa Costo totale Nessun dato ECOLE NATIONALE DE MEDICINE VETERINAIRE Tunisia Contributo UE Nessun dato Indirizzo 2020 SIDI THABET Mostra sulla mappa Costo totale Nessun dato INSTITUT PASTEUR DE TUNIS Tunisia Contributo UE Nessun dato Indirizzo 13,Place Pasteur 13 1002 TUNIS Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF GLASGOW Regno Unito Contributo UE Nessun dato Indirizzo Bearsden Road G61 1QH GLASGOW Mostra sulla mappa Costo totale Nessun dato UTRECHT UNIVERSITY Paesi Bassi Contributo UE Nessun dato Indirizzo Yalelaan 1 3584 CL UTRECHT Mostra sulla mappa Costo totale Nessun dato