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An investigation of the mechanism of action of growth hormone secretagogues for improving body composition and quality of life in the aged

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The age-related decline in endocrine function plays an important role in many of the changes in body composition and brain function that form part of the aging process. We propose to carry out studies in animals investigating how synthetic growth hormone secretagogues (GHS) act to improve body composition and brain function. Electrophysiological and neuroanatomical studies will determine how GHS interact with the brain pathways controlling growth hormone secretion, appetite and metabolism. Chronic GHS exposure will result in a new equilibrium of endocrine and CNS activity - we will study the consequences of long-term GHS exposure on hypothalamic gene expression and body composition. Studies of GHS action in animals with deletions in specific genes will identify the key sites of action of these compounds. Studies in obese diabetic animals (i.e. with symptoms of syndrome X) will include effects of GHS agonists and antagonists on the progression of the disease. Finally, since GHS increase circulating levels of insulin-like growth factors, we will determine the effects of GHS in the central IGF system, that has a protective role against neurodegeneration

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
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Downing Street
CB2 3EG Cambridge
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Letzte Aktualisierung: 12 April 2005

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/QLK6-CT-1999-02038/de

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