Objetivo The objectives of Neavac-Ec are :1) to increase knowledge of immunological factors which, in early infancy, lead to a high susceptibility to infectious diseases and to relatively weak vaccine-induced responses;2) to define optimal vaccine design and new immunization strategies for the rapid induction, in early life, of protective vaccine responses and long lasting immunological memory; 3)to identify and standardize suitable evaluation procedures (in vitro/in vivo, animal models/human, Dendrite Cell (DC), T and B cells responses) for the initial assessment of future vaccines/ delivery systems/ adjuvant considered for use in early life. A Tran disease approach has been adopted, focusing on(I) analysis of the Maturation of early life immune responses in humans and animal models and(ii) optimisation of vaccines against 3 selected important early life pathogens (S.pneumoniae B. peruses, Respiratory Syncytial Virus). This should contribute to establishing the generic principles of early life immunization and promote their concrete application to the industrial development of vaccines of high priority for both human and veterinary diseases.The overall achievements of Neovac have been more extensive that what could be expected. Substantial progress has been made towards a better understanding of the basic aspects of immune responses to vaccines in the neonatal period, particularly at the level of dendritic cells, opening the way to the design of appropriate vaccine formulations. In addition, results of considerable practical importance were obtained:- A new vaccinations strategy has been defined that may open the way to neonatal prevention of early life Pertussis.- Innovative immunisation approaches that are based on novel adjuvants, new formulations or new carriers were shown to be effective in models of early life diseases caused by RSV or Pneumococcus.These discoveries have a real potential to influence future vaccination programmes and to have an impact on disease burden resulting from these infections, not only in Europe but as well at global level. Ámbito científico medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-2. - Key action Control of Infectious Diseases Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador AVENTIS PASTEUR SA Aportación de la UE Sin datos Dirección 1541,Avenue Marcel Mérieux 1541 69280 MARCY-L'ETOILE Francia Ver en el mapa Coste total Sin datos Participantes (11) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CHIRON S.R.L. Italia Aportación de la UE Sin datos Dirección VIA FIORENTINA 1 53100 SIENA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Reino Unido Aportación de la UE Sin datos Dirección South Kensington Campus LONDON Ver en el mapa Coste total Sin datos INSTITUT PASTEUR Francia Aportación de la UE Sin datos Dirección Rue du Docteur Roux 25 75724 PARIS Ver en el mapa Coste total Sin datos INSTITUT PASTEUR DE LILLE Francia Aportación de la UE Sin datos Dirección Rue du Professeur Calmette 1 INSERM U168 59019 Lille Ver en el mapa Coste total Sin datos NATIONAL UNIVERSITY OF IRELAND, DUBLIN Irlanda Aportación de la UE Sin datos Dirección Belfield DUBLIN Ver en el mapa Coste total Sin datos PIERRE FABRE MEDICAMENT S.A. Francia Aportación de la UE Sin datos Dirección Avenue Napoléon III , 5 Le Puy Saint Martin 74164 SAINT JULIEN-EN-GENEVOIS Ver en el mapa Coste total Sin datos THE SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES Suecia Aportación de la UE Sin datos Dirección 10,Arrheniusplan 2C 750 07 UPPSALA Ver en el mapa Coste total Sin datos THE UNIVERSITY OF LIVERPOOL Reino Unido Aportación de la UE Sin datos Dirección Senate House, Abercromby Square L69 3SG LIVERPOOL Ver en el mapa Coste total Sin datos UNIVERSITY COLLEGE LONDON Reino Unido Aportación de la UE Sin datos Dirección 30,Guilford Street 30 WC1N 1EH LONDON Ver en el mapa Coste total Sin datos UNIVERSITY OF GENEVA Suiza Aportación de la UE Sin datos Dirección 24,Rue General Dufour 24 1211 GENEVE Ver en el mapa Coste total Sin datos Universite Libre de Bruxelles Bélgica Aportación de la UE Sin datos Dirección Avenue Franklin Roosevelt 50 BRUXELLES Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
