Cel European Union Alzheimer's disease (AD) and related dementias affect 5% of persons aged 65-70 years, rising to 20% in those aged 85 and over. The full costs of AD to EU nations are very high. Due to demographic changes within Europe, the prevalence of AD and costs to the EU are likely to increase dramatically over the next four decades. There are currently no effective therapies for AD. Deposition of amyloidal beta peptide (Abita) within the brains of AD patients is believed to be central to the pathogenesis of the disease. Abita is derived by proteolysis cleavage from the precursor protein. APP. Recently, two families pf proteins, the Fe65s and Axis, have been shown to bind to APP and significantly influence APP processing and Abita production. The purpose of this project is to understand further the mechanisms by witch Fee and X11a influence APP processing and Abita production in AD. Another objective of the project is to explore the relevance of a recently discovered phenomenon (molecular misreading) witch causes the accumulation in AD brains of aberrant proteins. This work will lead to the generation of new AD animal models and to relevant knowledge to design innovative therapeutic strategies and new diagnostic tools. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicineneurologydementiaalzheimer Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-6. - Key action The Ageing Population and Disabilities Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Wkład UE Brak danych Adres Via Sergio Pansini 5 80131 Napoli Włochy Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko KING'S COLLEGE LONDON Zjednoczone Królestwo Wkład UE Brak danych Adres De Crespigny Park W8 7AH LONDON Zobacz na mapie Koszt całkowity Brak danych ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCE Niderlandy Wkład UE Brak danych Adres Meibergdreef 33 1105 AZ AMSTERDAM Zobacz na mapie Koszt całkowity Brak danych
