Objetivo With current life expectancy, osteoporosis related fractures are a considerable health care problem. The precise anatomical changes, which lead to diminish bone quality, are unknown. Bone loss occurs with ageing and estrogens deficient subjects and is generally measured by the amount of bone mass, which only partly explains the increased fracture risk. More accurate diagnoses can be made if bone quality is measured by geometry, architecture and matrix tissue properties also. However, these cannot be measured in vivo, yet. The proposed project will use a newly developed micro-CT scanner to follow the architectural changes in the bones of animals as a function of ageing, estrogens deficiency and drug treatment. The mechanical consequences of architectural changes or matrix tissue changes will precisely be determined using computer models and micro mechanical testing, witch will provide new information with respect to aetiology and osteoporosis treatment.Achievements from objective:The innovative in-vivo micro-CT scanner designed by Skyscan is marketed now and a number of them has been already sold. Our initiative has received considerable attention by other players in the field. Two other manufacturers have now in-vivo micro-CT scans on the market as well. Recently a discussion list on internet was started by the Erasmus group www.lsoft.com/scripts/wl.exe?SL1=3DMORPH-L&H=NIC.SURFNET.NL In the third year (2002) most of the animal experiments (plus in-vivo scans) that where pivotal in the project were made. Academic partners have received bones from this experiment I the course of 2002 and 2003 and have performed various experiments with these bones according to the protocols they have set up in the first and second year (2000 & 2001).Hence, the most important result in the third year was the generation of the in-vivo CT scans, how they could be turned into follow-up data for the individual animals (by registration of the sequential data) and corresponding bone quality data. Currently the academic groups are working on the final deliverables. There is still a vast amount of data-mining to be performed. The academic groups will likely keep working with this data for a few years. In addition some data sets have been made public (downloadable from our web site) and given the amount of requests so far it seems likely that other academic research groups will use parts of our data for further research. Correspondence and some data sharing is done on the website (http://www.mme.tcd.ie/MIAB). Ámbito científico natural sciencescomputer and information sciencesinternetengineering and technologymedical engineeringdiagnostic imagingcomputed tomographynatural sciencesmathematicspure mathematicsgeometry Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador ERASMUS UNIVERSITEIT ROTTERDAM Aportación de la UE Sin datos Dirección Burgemeester Oudlaan 50 3000 DR ROTTERDAM Países Bajos Ver en el mapa Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo INSTITUTE OF FUNDAMENTAL TECHNOLOGICAL RESEARCH - POLISH ACADEMY OF SCIENCES Polonia Aportación de la UE Sin datos Dirección Swietokrzyska 21 00 049 WARSZAWA Ver en el mapa Coste total Sin datos KAZIMIERZ WIELKI - BYDGOSZCZ UNIVERSITY Polonia Aportación de la UE Sin datos Dirección Chodkiewicza, 30 80-064 BYDGOSZCZ Ver en el mapa Coste total Sin datos ORGANON NV Países Bajos Aportación de la UE Sin datos Dirección Molenstraat 110 5340 BH OSS Ver en el mapa Coste total Sin datos SKYSCAN B.V.B.A. Bélgica Aportación de la UE Sin datos Dirección Kolonel Bourgstraat 106 B1 1040 BRUXELLES Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN Irlanda Aportación de la UE Sin datos Dirección Trinity College 2 DUBLIN Ver en el mapa Coste total Sin datos UNIVERSITAIR CENTRUM ANTWERPEN - UNIVERSITEIT ANTWERPEN Bélgica Aportación de la UE Sin datos Dirección Groenenborgerlaan 171 2018 ANVERS /ANTWERPEN Ver en el mapa Coste total Sin datos UNIVERSITY OF AARHUS Dinamarca Aportación de la UE Sin datos Dirección 1,Nordre Ringgade 1-3 8000 AARHUS C Ver en el mapa Coste total Sin datos