Objective The experimental approach and different levels of analysis is aimed at understanding the molecular and cellular early phases of the neurodegeneration in Alzheimer's disease. This is not possible in humans and requires animal models that allow invasive analysis. Transgenic mice expressing human AD related genes (APP, PS1, Ape) have been and continue to be generated and will be validated. They will extend and recapitulate new findings in less complex systems, implemented in this proposal. "Multiple" transgenic mouse strains with more than one human transgenic are expected to show more complete pathology. Most important aspect addressed will be fundamental aspects of amyloidogenesis relating to the role of Personalise and its path physiological sequels on cognition, behaviour, neuropathology, oxidative stress, calcium homeostasis, protein degradation and modifying proteins. Fields of science natural sciencesbiological scienceszoologymammalogyprimatologymedical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator KATHOLIEKE UNIVERSITEIT LEUVEN EU contribution No data Address Oude Markt 13 3000 LOUVAIN / LEUVEN Belgium See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all 'NENCKI' INSTITUTE OF EXPERIMENTAL BIOLOGY - POLISH ACADEMY OF SCIENCES Poland EU contribution No data Address Pasteur Street 3 02 093 WARSZAWA See on map Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Boulevard de l'Hôpital 83 CERVI 75013 PARIS See on map Total cost No data LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Germany EU contribution No data Address Geschwister-Scholl-Platz 1 80539 MUENCHEN See on map Total cost No data