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Validation of single and multiple mice models for alzheimer's disease.

Objective

The experimental approach and different levels of analysis is aimed at understanding the molecular and cellular early phases of the neurodegeneration in Alzheimer's disease. This is not possible in humans and requires animal models that allow invasive analysis. Transgenic mice expressing human AD related genes (APP, PS1, Ape) have been and continue to be generated and will be validated. They will extend and recapitulate new findings in less complex systems, implemented in this proposal. "Multiple" transgenic mouse strains with more than one human transgenic are expected to show more complete pathology. Most important aspect addressed will be fundamental aspects of amyloidogenesis relating to the role of Personalise and its path physiological sequels on cognition, behaviour, neuropathology, oxidative stress, calcium homeostasis, protein degradation and modifying proteins.

Call for proposal

Data not available

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
EU contribution
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Address
Oude Markt 13
3000 LOUVAIN / LEUVEN
Belgium

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Total cost
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Participants (3)