Objective The recent discovery of radiation-induced genomic instability has raised concern for its implication in the radiation protection of the public, especially, quantification of human risk for low doses and high LET exposure. The role of radiation-induced genomic instability in radiation carcinogenesis will be studied with animal models and mechanistic investigations of induction and transmission. Genes and genome regions involved will be studied and the basis of individual susceptibility investigated. The relationship of genomic instability endpoints to radiation dose, dose rate and quality will be determined. The proposal brings together all major European laboratories involved in the discovery, characterization and mechanistic investigation of radiation-induced genomic instability. A state of the art working document on the relevance of genomic instability for cancer risk assessment will be prepared for the use of European decision makers. Fields of science medical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator RADIATION AND NUCLEAR SAFETY AUTHORITY EU contribution No data Address 4,Laippatie 4 00881 HELSINKI Finland See on map Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address Avenue du General Leclerc 60-68 92265 FONTENAY AUX ROSES See on map Total cost No data DUBLIN INSTITUTE OF TECHNOLOGY Ireland EU contribution No data Address 40-41,Kevin Street 40-41 Moravian Church 8 DUBLIN See on map Total cost No data GRAY LABORATORY CANCER RESEARCH TRUST United Kingdom EU contribution No data Address Mount Vernon Hospital HA6 2JR NORTHWOOD See on map Total cost No data GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Germany EU contribution No data Address Ingolstaedter Landstrasse 1 85764 OBERSCHLEISSHEIM See on map Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address Haelsvaegen 7 141 57 Huddinge See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Harwell OX11 0RD Didcot See on map Total cost No data UNIVERSITY OF DUNDEE United Kingdom EU contribution No data Address DD1 9SY DUNDEE See on map Total cost No data University of Cambridge United Kingdom EU contribution No data Address Downing Street CB2 3DY Cambridge See on map Total cost No data
