Obiettivo The recent discovery of radiation-induced genomic instability has raised concern for its implication in the radiation protection of the public, especially, quantification of human risk for low doses and high LET exposure. The role of radiation-induced genomic instability in radiation carcinogenesis will be studied with animal models and mechanistic investigations of induction and transmission. Genes and genome regions involved will be studied and the basis of individual susceptibility investigated. The relationship of genomic instability endpoints to radiation dose, dose rate and quality will be determined. The proposal brings together all major European laboratories involved in the discovery, characterization and mechanistic investigation of radiation-induced genomic instability. A state of the art working document on the relevance of genomic instability for cancer risk assessment will be prepared for the use of European decision makers. Campo scientifico medical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsgenomes Programma(i) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Argomento(i) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore RADIATION AND NUCLEAR SAFETY AUTHORITY Contributo UE Nessun dato Indirizzo 4,Laippatie 4 00881 HELSINKI Finlandia Mostra sulla mappa Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto COMMISSARIAT A L'ENERGIE ATOMIQUE Francia Contributo UE Nessun dato Indirizzo Avenue du General Leclerc 60-68 92265 FONTENAY AUX ROSES Mostra sulla mappa Costo totale Nessun dato DUBLIN INSTITUTE OF TECHNOLOGY Irlanda Contributo UE Nessun dato Indirizzo 40-41,Kevin Street 40-41 Moravian Church 8 DUBLIN Mostra sulla mappa Costo totale Nessun dato GRAY LABORATORY CANCER RESEARCH TRUST Regno Unito Contributo UE Nessun dato Indirizzo Mount Vernon Hospital HA6 2JR NORTHWOOD Mostra sulla mappa Costo totale Nessun dato GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Germania Contributo UE Nessun dato Indirizzo Ingolstaedter Landstrasse 1 85764 OBERSCHLEISSHEIM Mostra sulla mappa Costo totale Nessun dato KAROLINSKA INSTITUTE Svezia Contributo UE Nessun dato Indirizzo Haelsvaegen 7 141 57 Huddinge Mostra sulla mappa Costo totale Nessun dato MEDICAL RESEARCH COUNCIL Regno Unito Contributo UE Nessun dato Indirizzo Harwell OX11 0RD Didcot Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF DUNDEE Regno Unito Contributo UE Nessun dato Indirizzo DD1 9SY DUNDEE Mostra sulla mappa Costo totale Nessun dato University of Cambridge Regno Unito Contributo UE Nessun dato Indirizzo Downing Street CB2 3DY Cambridge Mostra sulla mappa Costo totale Nessun dato
