Cel To advance our understanding of radiation carcinogenesis and to obtain information relevant to radiation protection and the management of patients with radiation induced thyroid tumours we propose to carry out an integrated study of morphological, cell and molecular biological and clinical aspects of thyroid tumours from patients exposed to high levels of fallout from the Chernobyl accident. We will utilise the unique resource of paired tumour/normal tissue samples from these patients, carry out the study in leading European centres, using novel techniques of cell cycle analysis, DNA chip technology, FISH and analysis of DNA repair mechanisms. These studies will be carried out on the same tumours and the results will be correlated with careful diagnosis, morphological analysis of the tumour samples and evidence of clinical outcome to provide a comprehensive study of the defects involved in radiation carcinogenesis and their relevance to diagnosis and tumour behaviour.181 cases studied, morphological data completed on all and molecular biological data on ret completed on 162 assayable cases. RFG and mutant protein studies nearing completion. Microarray analysis completed on a subset of tumours - no differences observed between post Chernobyl cancers and those of non radiation aetiology. Rearrangements identified by FISH and correlated with RT-PCR data. Database complete and ready to undergo analysis for correlation with morphology and clinical presentation. Large dataset ready for transfer to the Chernobyl Tissue Bank for integration with other projects. 13 papers published, submitted or in press - more in preparation. Dziedzina nauki natural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncology Program(-y) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Temat(-y) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator UNIVERSITY OF WALES SWANSEA Wkład UE Brak danych Adres Singleton Park SA2 8PP SWANSEA Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Niemcy Wkład UE Brak danych Adres Ingolstädter Landstrasse 1 85764 Neuherberg Zobacz na mapie Koszt całkowity Brak danych INSTITUTE OF ENDOCRINOLOGY AND METABOLISM - ACADEMY OF MEDICAL SCIENCES OF THE UKRAINE Ukraina Wkład UE Brak danych Adres 69,Vyshgorodskaya Street 69 254114 KIEV Zobacz na mapie Koszt całkowity Brak danych UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Włochy Wkład UE Brak danych Adres Via Sergio Pansini 5 80131 NAPOLI Zobacz na mapie Koszt całkowity Brak danych UNIVERSITE LIBRE DE BRUXELLES Belgia Wkład UE Brak danych Adres 808,Route de Lennik 808 Campus Erasme - Building C 1070 BRUXELLES Zobacz na mapie Koszt całkowity Brak danych University of Cambridge Zjednoczone Królestwo Wkład UE Brak danych Adres Tennis Court Road CB2 1QP Cambridge Zobacz na mapie Koszt całkowity Brak danych
