Cel Malaria vaccines are urgently required. Recombinant multi-component cocktail vaccines are currently favoured. Using very recent technological advances this programme revives the concept of attenuated parasites as vaccines. It bring together for the first leading EU and African groups to develop methodologies allowing the design and creation of parasites with properties desirable in such a vaccine. The ultimate delivery of such a vaccine may be as either sexually incompetent, genetically restricted parasites, or as transmissible self-spreading forms. For either route certain fundamental pre-conditions must be met, and these are the major focus of this proposal; Systems will be developed to provide1) auxotrophic parasites2) sequential unrestricted genetic manipulation of parasites3) axenic culture4) parasite knock outs for specific genes and5) immuno-potentiated parasites through heterologous gene expression. In combination with a dialogue across scientific and public interests this programme will enable the partnership to provide a clear assessment of the feasibility of vaccination with genetically modified malaria within three years. Dziedzina nauki medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Program(-y) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator LEIDEN UNIVERSITY Wkład UE Brak danych Adres Wassenaarseweg 72 2333 AL LEIDEN Niderlandy Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Niderlandy Wkład UE Brak danych Adres 151,Lange Kleiweg 151 2280 GH RIJSWIJK ZH Zobacz na mapie Koszt całkowity Brak danych MED BIOTECH LABORATORIES Uganda Wkład UE Brak danych Adres Sekindi Close Plot 3438 - Myenga 10 KAMPALA Zobacz na mapie Koszt całkowity Brak danych UNIVERSITAETSKLINIKUM HEIDELBERG Niemcy Wkład UE Brak danych Adres Im Neuenheimer Feld 324 69120 Heidelberg Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY COLLEGE OF IBADAN Nigeria Wkład UE Brak danych Adres University College Hospital IBADAN Zobacz na mapie Koszt całkowity Brak danych
