Cel The fight against infectious agents is focused to an efficient treatment of the diseases associated with infections and to the prevention of them. Regarding prevention, the most cost-effective strategy is vaccination. Classical vaccines have used microbe molecules such as cell invasion proteins, critical virulence factors on highly antigenic molecules. However, most of these vaccines have failed to achieve good protection against intracellular bacteria. The most putative reason resides in the ability of microbes to elude the immune response by evolving specific mechanisms to interfere with celldegradative routes (i.e. natural cell defences). Intracellular pathogens could share analogous strategies and compounds for this interference and their characterization will be critical for new and effective vaccines that confer protection against more than one pathogen. On this regard, we plan to design an innovative live, recombinant multi competent vaccine for brucellosis and tuberculosis. Our approach will try to identify and construct a vaccine including the microbe molecules responsible for interfering with cell derivative mechanisms (i.e. the phagosomal transport of lysosomal proteins). Dziedzina nauki natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Program(-y) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Wkład UE Brak danych Adres Universidad Autonoma de Madrid, Cantoblanco 28049 MADRID Hiszpania Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francja Wkład UE Brak danych Adres Parc Scientifique et Technologique de Luminy 13288 MARSEILLE Zobacz na mapie Koszt całkowity Brak danych INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS Wenezuela Wkład UE Brak danych Adres Carreterra Panamericana KM11 1020A CARACAS Zobacz na mapie Koszt całkowity Brak danych UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO Meksyk Wkład UE Brak danych Adres Circuito Interior 04510 MEXICO D.F. Zobacz na mapie Koszt całkowity Brak danych UNIVERSIDAD NACIONAL COSTA RICA Kostaryka Wkład UE Brak danych Adres 3000 HEREDIA Zobacz na mapie Koszt całkowity Brak danych
