Objectif i) Application of early neurodevelopmental tests in infants with different pre- and postnatal PCB-levelsii) Validation of such indicators using behavioural and cognitive criteria at different age levels until age 42 monthsiii) Testing the impact of early environmental PCB-exposure for neurological and neurophysiological development.Epidemiological findings on neuromotor and neurobehavioural developmental deficit associated with early exposure to PCBs, although generally consistent, nevertheless present some uncertainties. The most prominent of these include uncertain causality, disagreement in terms of the spectrum of effects, and inconsistency regarding the persistence of deficit.The planned prospective study aims at clarifying some of these uncertainties. It expands on an ongoing clinical research programme in the Netherlands, in which 200 newborns each are sampled at the Department of Obstetrics and Gynaecology of the State University Groningen and at the Sophia Children's Hospital in Rotterdam. In particular, this project will:i) Extend the observation period beyond age 18 until age 42 months in part of the Dutch sample, andii) Add extreme groups of between 200 and 300 newborns from the University Child Clinic in Düsseldorf.The Dutch and the German contributions are planned to be complementary in terms of the covered observation period, the general sampling strategy, and a partly different spectrum of outcome measures.The basic unifying exposure variable is the PCB cordblood level. Ring-tests will be organized to ensure comparability and quality of these data. The study protocol covers both essential and optional outcome variables. Essential variables include the early assessment of sensorimotor and neurological status according to TOUWEN & PRECTHL (age 10 d), the BAYLEY SCALES OF INFANT DEVELOPMENT and the FAGAN-Test (age 7 mo), the BAYLEY Scales at age 18 months and the KAUFMAN Assessment Battery as well as the REYNELL Language Scales at age 42 months. In addition, in the German sample, a digitized analysis of spontaneous infant vocalizations will be performed at ages 7 and 12 months according to recently developed methods. Data will be analyzed by means of multiple regression analysis taking confounding variables into account. Champ scientifique medical and health sciencesclinical medicineobstetricsmedical and health sciencesclinical medicinegynaecology Programme(s) FP3-ENV 1C - Specific research and technological development programme (EEC) in the field of the environment, 1990-1994 Thème(s) 040203 - Environment and human health Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur GESELLSCHAFT ZUR FOERDERUNG DER LUFTHYGIENE UND SILIKOSEFORSCHUNG E.V. Contribution de l’UE Aucune donnée Adresse Auf'm Hennekamp 50 40225 DUESSELDORF Allemagne Voir sur la carte Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Erasmus Universiteit Rotterdam Pays-Bas Contribution de l’UE Aucune donnée Adresse 600,Dr. Molewaterplein 600 3015 GJ Rotterdam Voir sur la carte Coût total Aucune donnée Heinrich-Heine-Universität Düsseldorf Allemagne Contribution de l’UE Aucune donnée Adresse Moorenstraße 5 40225 Düsseldorf Voir sur la carte Coût total Aucune donnée Heinrich-Heine-Universität Düsseldorf Allemagne Contribution de l’UE Aucune donnée Adresse Moorenstraße 5 40225 Düsseldorf Voir sur la carte Coût total Aucune donnée Rijksuniversiteit Groningen Pays-Bas Contribution de l’UE Aucune donnée Adresse 59,Oostersingel 9713 KZ Groningen Voir sur la carte Coût total Aucune donnée