Objective Extensive death of nerve cells may no longer be considered as a major event in the process of normal ageing of the nervous system (except in pathological conditions). In addition, the ageing brain and nerves retain sufficient plasticity for regeneration. This means that treating normal age-related dysfunctions of the nervous system, such as memory loss, will become possible. Indeed, research carried out in the laboratories of the partners has shown that age-related memory deficits and abnormalities of myelin sheaths (which isolate nerve fibres) can be reversed by the administration of neurosteroids (steroids which can be locally synthesised in the nervous system). Two complementary therapeutic strategies will be explored:1) Increasing the local synthesis of neurosteroids by agonists of themitochondrial benzodiazepine receptor;2) administering selective neurosteroidcompounds. Fields of science natural sciencesbiological sciencesneurobiology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE EU contribution No data Address 80,Avenue de Général Leclerc 80 94276 LE KREMLIM BICETRE France See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOLOGICAL RESEARCH CENTRE - HUNGARIAN ACADEMY OF SCIENCES Hungary EU contribution No data Address 62,Temesvari Krt. 62 6762 SZEGED See on map Total cost No data CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution No data Address Av. Doctor Arce 37 28002 MADRID See on map Total cost No data THE UNIVERSITY OF MILANO Italy EU contribution No data Address Via Balzaretti 9 20133 MILANO See on map Total cost No data UNIVERSITY OF DUNDEE United Kingdom EU contribution No data Address Ninewells Hospital & Medical School DD1 9SY DUNDEE See on map Total cost No data University of Cambridge United Kingdom EU contribution No data Address Madingley Road CB3 0ES Cambridge See on map Total cost No data