Obiettivo Extensive death of nerve cells may no longer be considered as a major event in the process of normal ageing of the nervous system (except in pathological conditions). In addition, the ageing brain and nerves retain sufficient plasticity for regeneration. This means that treating normal age-related dysfunctions of the nervous system, such as memory loss, will become possible. Indeed, research carried out in the laboratories of the partners has shown that age-related memory deficits and abnormalities of myelin sheaths (which isolate nerve fibres) can be reversed by the administration of neurosteroids (steroids which can be locally synthesised in the nervous system). Two complementary therapeutic strategies will be explored:1) Increasing the local synthesis of neurosteroids by agonists of themitochondrial benzodiazepine receptor;2) administering selective neurosteroidcompounds. Campo scientifico natural sciencesbiological sciencesneurobiology Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-6. - Key action The Ageing Population and Disabilities Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Contributo UE Nessun dato Indirizzo 80,Avenue de Général Leclerc 80 94276 LE KREMLIM BICETRE Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BIOLOGICAL RESEARCH CENTRE - HUNGARIAN ACADEMY OF SCIENCES Ungheria Contributo UE Nessun dato Indirizzo 62,Temesvari Krt. 62 6762 SZEGED Mostra sulla mappa Costo totale Nessun dato CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spagna Contributo UE Nessun dato Indirizzo Av. Doctor Arce 37 28002 MADRID Mostra sulla mappa Costo totale Nessun dato THE UNIVERSITY OF MILANO Italia Contributo UE Nessun dato Indirizzo Via Balzaretti 9 20133 MILANO Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF DUNDEE Regno Unito Contributo UE Nessun dato Indirizzo Ninewells Hospital & Medical School DD1 9SY DUNDEE Mostra sulla mappa Costo totale Nessun dato University of Cambridge Regno Unito Contributo UE Nessun dato Indirizzo Madingley Road CB3 0ES Cambridge Mostra sulla mappa Costo totale Nessun dato
