Objetivo BACKGROUND: Menopause is a milestone in the ageing process in women, and the cessation of secretion of ovarian estrogens after menopause has a major impact on healthy ageing of women and their quality of life. One of the main determinants of the timing of menopause is the efficiency of the use of the primordial follicle stock. AIM: the determination of the role of anti-mullein hormone (AMH), growth and differentiation factor-9 and -9B (GDF9, GDF9B) in primordial follicle loss. OBJECTIVES and EXPECTED RESULTS:(1) the development of large-scale production of AMH and GDF919B and of specific and sensitive assays to determine AMH and GDF9/9B in biological samples;(2) the investigation of the role of AMH and GDF9/9B in early follicular development in women and in mice;(3) the identification of regulated target genes of AMH and GDF9/9B in developing follicles. Programa(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Tema(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador ERASMUS UNIVERSITEIT ROTTERDAM Aportación de la UE Sin datos Dirección 50,Dr. Molewaterplein 50 3015 GE ROTTERDAM Países Bajos Ver en el mapa Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo OXFORD BROOKES UNIVERSITY Reino Unido Aportación de la UE Sin datos Dirección Gipsy Lane OX3 0BP OXFORD/HEADINGTON Ver en el mapa Coste total Sin datos UNIVERSITY OF HELSINKI Finlandia Aportación de la UE Sin datos Dirección Haartmaninkatu 3 00014 HELSINKI Ver en el mapa Coste total Sin datos UNIVERSITY OF KUOPIO Finlandia Aportación de la UE Sin datos Dirección 2,Neulaniementie 2 70211 KUOPIO Ver en el mapa Coste total Sin datos