Obiettivo A large percentage of tumours from hereditary non-polyposis colon cancer (HNPCC) patients, as well as more than 15% of sporadic colon tumours, display micro satellite instability (MSI) , which has been linked to a defect in mismatch correction (MMR) . Tumour cells with high MSI (MSI-H) differ from other cancer cells: they are largely diploid and the oncogenes and tumour suppressor genes mutated in them are frequently different from those altered in sporadic disease without MSI. We shall compare the response of normal and MSI-H cells to a series of chemotherapeutic and radiomimetic agents, as well as to ionising and non-ionising radiation. The principal aim of this program is to exploit the identified differences in cancer therapy, by devising ways of selectively killing cells with MSI. The second goal of the study is to use our findings to develop new, facile, diagnostic strategies for the identification of at-risk individuals. Campo scientifico engineering and technologymechanical engineeringvehicle engineeringaerospace engineeringsatellite technologymedical and health sciencesclinical medicineoncologycolorectal cancer Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore LEIDEN UNIVERSITY Contributo UE Nessun dato Indirizzo 72,Wassenaarseweg 72 2333 AL LEIDEN Paesi Bassi Mostra sulla mappa Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CANCER RESEARCH INSTITUTE - SLOVAK ACADEMY OF SCIENCES Slovacchia Contributo UE Nessun dato Indirizzo 59,Vlarska 7 833 91 BRATISLAVA Mostra sulla mappa Costo totale Nessun dato ISTITUTO SUPERIORE DI SANITA Italia Contributo UE Nessun dato Indirizzo Viale Regina Elena 299 00161 ROMA Mostra sulla mappa Costo totale Nessun dato PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELL'IMMACOLATA CONCEZIONE - ISTITUTO DERMOPATICO DELL'IMMACOLATA Italia Contributo UE Nessun dato Indirizzo Via dei Monti di Creta 104 00167 ROMA Mostra sulla mappa Costo totale Nessun dato ROSKILDE UNIVERSITY Danimarca Contributo UE Nessun dato Indirizzo 35,Universitetsvej 1 4000 ROSKILDE Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF ZURICH Svizzera Contributo UE Nessun dato Indirizzo August Forel-Strasse 7 8008 ZURICH Mostra sulla mappa Costo totale Nessun dato
