Objectif This project aims at designing a new therapeutic approach for the restoration of sensory function after damage in the inner ear auditory and balance organs. This goal will be reached through the better understanding of the regenerative and "neo-synaptogenesis" potential of inner ear sensory neurons and on how this potential can be enhanced in vivo in hearing impaired animals. Stem cell lines from normal animals and form transgenic animals over expressing neurotrophic factors will be established and these cells will be further manipulated using genetic engineering. The ability of these cells to support regeneration in the inner ear will be assessed with functional in vitro and in vivo approaches. This cell therapy approach will be combined with existing biopolymer implants and with existing cochlear electrode prosthesis into a BIOELECTRODE implant. Champ scientifique medical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesmedical biotechnologyimplants Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-9. - Neurosciences Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Contribution de l’UE Aucune donnée Adresse Avenue du Fontaule 1 66651 BANYULS SUR MER France Voir sur la carte Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire KAROLINSKA INSTITUTE Suède Contribution de l’UE Aucune donnée Adresse Novum, KFC plan 4 141 86 STOCKHOLM Voir sur la carte Coût total Aucune donnée NATIONAL RESEARCH COUNCIL OF ITALY Italie Contribution de l’UE Aucune donnée Adresse Via Vanvitelli 32 20129 MILANO Voir sur la carte Coût total Aucune donnée SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE Suisse Contribution de l’UE Aucune donnée Adresse AAB 132 1015 LAUSANNE Voir sur la carte Coût total Aucune donnée
