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Control of specification and migration of oligodendrocytes

Ziel

The study of cellular and molecular mechanisms underlying oligodendrocytedevelopment is a prerequisite to understand pathologies linked to myelin dysfunction. During development, the oligodendroglial specification of intraepithelial cells is a process spatially restricted which gives rise to a diversity of oligodendrocyte cells types. The aim of our project is to study, from multidisciplinary approaches (molecular and cellular) and in different animal models (Drosophilae, chick, mouse):
i) the developmental mechanisms regulating the oligodendrogenesis from undifferentiated intraepithelial precursors: focusing on genetic cascade that controls the choice of oligodendroglial lineage; and
ii) the biological consequences of molecular and spatial differentiate characters of oligodendrocyte progenitors; focusing the migration patterns and their molecular control.

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Koordinator

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
EU-Beitrag
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Adresse
Campus de San Juan - Ctra Alicante-Valencia Km 8,7
03550 SAN JUAN DE ALICANTE
Spanien

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Beteiligte (6)