Objectif The aim is to identify and exploit viral modifiers of apoptosis and cytokine responses (particularly Toners) as a potential source of novel health care pharmaceuticals for manipulation of immune responses and treatment of certain diseases. Such virus genes will be identified by nucleotide sequence and functional analysis of cloned viral Orbs and coda libraries of three large DNA viruses (African swine fever, Extremely and Mouse herpes). Possible human homologue of novel sequences will be characterised. The cellular targets of these viral evasion genes and their impact on apoptosis and virus pathogenesis will be determined. Determination of minimal active sequences will permit the development of low molecular weight peptide drugs, starting with the calcineurin phosphates inhibitor A238L gene of ASFV. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicineimmunologynatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysismedical and health scienceshealth sciencesinfectious diseasesDNA viruses Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-3. - Key action The "Cell factory" Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur FUNDACAO CALOUSTE GULBENKIAN Contribution de l’UE Aucune donnée Adresse 6,Rua da Quinta Grande n°6 2780-156 OEIRAS Portugal Voir sur la carte Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUTE FOR ANIMAL HEALTH Royaume-Uni Contribution de l’UE Aucune donnée Adresse Ash Road, Nr Woking GU24 0NF WOKING Voir sur la carte Coût total Aucune donnée INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA Espagne Contribution de l’UE Aucune donnée Adresse 56,Carretera de la Coruça Km7.5 28014 MADRID Voir sur la carte Coût total Aucune donnée THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Royaume-Uni Contribution de l’UE Aucune donnée Adresse Tennis Court Road CB2 1QP CAMBRIDGE Voir sur la carte Coût total Aucune donnée
