Obiettivo Excessive use of pesticides in Europe has led to serious contamination of soil and water and presents growing threat to human and animal health. We propose to improve the sensitivity of biosensors used both for detecting incidental or chronic environmental contamination by ant cholinesterase pesticides and/or monitoring the efficiency of remediation of polluted sites. The enzyme acetyl cholinesterase is the target of organophosphates and carbonates, two major pesticides currently used in agriculture. We will employ a 'state-of-the-art' approach, utilizing X-ray crystallography, structure analysis, site-directed autogenesis and large-scale production, using suitable expression systems. This will enable us to produce new bio engineered targets both more sensitive to and more selective for pesticides of interest, and also possess creased stability. This will permit us to provide our industrial partner with deliverables suitable for production of novel biosensors possessing the specificity and shelf life required for manufacturing field kits. Campo scientifico engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsnatural scienceschemical sciencesinorganic chemistryinorganic compoundsnatural sciencesearth and related environmental sciencesgeologymineralogycrystallographyagricultural sciencesagriculture, forestry, and fisheriesagriculturenatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Parole chiave Nanotechnology Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-3. - Key action The "Cell factory" Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Contributo UE Nessun dato Indirizzo Place Pierre Viala 2 34060 Montpellier Francia Mostra sulla mappa Costo totale Nessun dato Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BST BIO SENSOR TECHNOLOGIE GMBH Germania Contributo UE Nessun dato Indirizzo 61,Buchholzer Strasse 61 13156 BERLIN Mostra sulla mappa Costo totale Nessun dato ECOLE NORMALE SUPERIEURE Francia Contributo UE Nessun dato Indirizzo Rue d'Ulm 46 75230 Paris Mostra sulla mappa Costo totale Nessun dato IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Regno Unito Contributo UE Nessun dato Indirizzo SW7 2AY London Mostra sulla mappa Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI PERUGIA Italia Contributo UE Nessun dato Indirizzo Via del Giochetto 06126 Perugia Mostra sulla mappa Costo totale Nessun dato UNIVERSITAET STUTTGART Germania Contributo UE Nessun dato Indirizzo Keplerstrasse 7 70174 STUTTGART Mostra sulla mappa Costo totale Nessun dato UNIVERSITE LIBRE DE BRUXELLES Belgio Contributo UE Nessun dato Indirizzo 50,Avenue F.D. Roosevelt 50 1050 BRUXELLES Mostra sulla mappa Costo totale Nessun dato UNIVERSITE PAUL SABATIER DE TOULOUSE III Francia Contributo UE Nessun dato Indirizzo Route de Narbonne 118 31062 TOULOUSE Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF BUCHAREST Romania Contributo UE Nessun dato Indirizzo Bd Mihail Kogalniceanu 64 Sector no 5 70609 BUCHAREST Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF LJUBLJANA Slovenia Contributo UE Nessun dato Indirizzo Vrazov Trg 2 1105 LJUBLJANA Mostra sulla mappa Costo totale Nessun dato WEIZMANN INSTITUTE OF SCIENCE Israele Contributo UE Nessun dato Indirizzo 2 Herzl Street 76100 REHOVOT Mostra sulla mappa Costo totale Nessun dato
