Objectif
The aim of the proposed study is to determine whether acute exposure to ambient air pollution increases the risk of acute hospitalisation and the risk of mortality in the general population and among population-based cohorts of patients who had survived a myocardial infarction (MI). A total of 29,OOO incident cases of non-fatal MI will be recruited through population registries in five European cities (Augsburg, Barcelona, Helsinki, Rome, Stockholm), and will be followed for at east one year to evaluate subsequent hospitalisation for a new MI or mortality (sudden deaths). Simultaneous measurement ofultrafine particulate matter will be conducted. The associations will be evaluated using a case-crossover approach. Since the unit of observation will be the individual, the study will be able to explore which characteristics of these patients confer major susceptibility to air pollution. A pooled analysis will be carried out. The results are relevant for European initiatives to implement targeted prevention strategies on air pollution, to release evidence-based guidelines for susceptible subgroups, and to develop dedicated early warning systems. The ultimate goal is to provide the scientific evidence for the revision of thee Directive on particulate matter and other urban air pollJlutants scheduled for the year 2003.
Champ scientifique
Appel à propositions
Data not availableRégime de financement
CSC - Cost-sharing contractsCoordinateur
00198 ROMA
Italie