Objectif Efficient and safe vectors for gene therapy of prostate and bladder cancer will be developed by modification of viruses with multivalent hydrophilic polymers. This approach is particularly powerful because it permits complete shielding of viral tropism without genetic engineering. The resulting vectors are less immunogenicthan normal viruses and will be targeted to tumour cell-surface receptors. Their infectivity of these vectors is not affected by neutralising antibodies in serum, a major limitation of current use of viruses for gene delivery - particularly in the clinics. Viruses retargeted in this way operate at a lower MOI than regular viruses in serum and maintain extremely high efficiency of gene expression. These vectors should provide an effective means to realise the substantial promise of gene therapy, and this proposal combines cell/molecular biology and virology with polymer chemistry in their development. Champ scientifique medical and health sciencesclinical medicineoncologyprostate cancermedical and health sciencesclinical medicineoncologybladder cancermedical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesmicrobiologyvirologynatural scienceschemical sciencespolymer sciences Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Contribution de l’UE Aucune donnée Adresse Woodstock Road OX2 6he OXFORD Royaume-Uni Voir sur la carte Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire CANCER RESEARCH INSTITUTE Espagne Contribution de l’UE Aucune donnée Adresse Autovia Castelldefels Km 2,7 08907 HOSPITALET DEL LLOBREGAT Voir sur la carte Coût total Aucune donnée INSTITUTE OF MACROMOLECULAR CHEMISTRY - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC Tchéquie Contribution de l’UE Aucune donnée Adresse 2,Heyrovsky Sq. 2 162 06 PRAHA 6 Voir sur la carte Coût total Aucune donnée