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Excitation-contraction coupling in the heart: regulmation of the calcium-release-chanel (crc) by post-translational modifications.

Ziel

The CRC plays a key role in excitation-contraction coupling, in the heart. The amount of Ca2+ that is released from the SR dictates the force of contraction. Elucidation of CRC regulation, at the molecular level, will enable us to design clinically-helpful agents that modulate cardiac contraction.

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MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE
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