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Role of ShcC adaptor protein in neuronal survival and differentiation

Objective

I will test if ShcC-driven signalling events in postmitotic neurons are critical for neuronal viability and phenotypic stability.

We will test this possibility by:
1) producing mice and derive cells in which mature neurons are deleted of ShcC in a constitutive or inducible manner
2) identifying promoter sequences and molicules important for ShcC expression in mature neurons
3) identifying the downstream signalling events initiated by ShcC in CNS neurons

Topic(s)

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Call for proposal

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Coordinator

The University of Edinburgh
EU contribution
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Address
West mains road, king's buildings
EH9 3JQ Edinburgh
United Kingdom

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Total cost
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Participants (1)