Objective I will test if ShcC-driven signalling events in postmitotic neurons are critical for neuronal viability and phenotypic stability.We will test this possibility by:1) producing mice and derive cells in which mature neurons are deleted of ShcC in a constitutive or inducible manner2) identifying promoter sequences and molicules important for ShcC expression in mature neurons3) identifying the downstream signalling events initiated by ShcC in CNS neurons Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) Data not available Call for proposal Data not available Funding Scheme RGI - Research grants (individual fellowships) Coordinator The University of Edinburgh EU contribution No data Address West mains road, king's buildings EH9 3JQ Edinburgh United Kingdom See on map Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Not available Italy EU contribution No data Address See on map Total cost No data